- 专利标题： Human-derived insect-resistant gene and anti-CRY1B toxin idiotype single-chain antibody encoded thereby and application thereof
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申请号： US15104127申请日： 2015-01-09
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公开(公告)号： US09770038B2公开(公告)日： 2017-09-26
- 发明人: Xianjin Liu , Chongxin Xu , Xiao Zhang , Yuan Liu , Yajing Xie , Cunzheng Zhang , Xiangyang Yu , Donglan Wang
- 申请人： JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
- 申请人地址： CN Xuanwu Nanjing
- 专利权人： JIANGSU ACADEMY OF AGRICULTURAL SCIENCES INSTITUTE OF FOOD SAFETY AND MONITORING TECHNOLOGY
- 当前专利权人： JIANGSU ACADEMY OF AGRICULTURAL SCIENCES INSTITUTE OF FOOD SAFETY AND MONITORING TECHNOLOGY
- 当前专利权人地址： CN Xuanwu Nanjing
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 优先权： CN201410037175 20140126
- 国际申请： PCT/CN2015/070421 WO 20150109
- 国际公布： WO2015/109952 WO 20150730
- 主分类号： A01N63/02
- IPC分类号： A01N63/02 ; C07K16/12 ; C12N15/70
摘要：
Provided are a human-derived insect-resistant gene having a nucleotide sequence represented by SEQ ID NO.1, and an anti-Cry1B toxin idiotype single-chain antibody encoded by said human-derived insect-resistant gene and having an amino acid sequence represented by SEQ ID NO.2. The idiotype single-chain antibody is a β-type and has insecticidal activity, and after expression by the prokaryotic system, the primary culture thereof has binding activity to Cnaphalocrocis medinalis midgut peritrophic membrane specific receptor BBMV.
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