Region of interest detection in raw time of flight images is described. For example, a computing device receives at least one raw image captured for a single frame by a time of flight camera. The raw image depicts one or more objects in an environment of the time of flight camera (such as human hands, bodies or any other objects). The raw image is input to a trained region detector and in response one or more regions of interest in the raw image are received. A received region of interest comprises image elements of the raw image which are predicted to depict at least part of one of the objects. A depth computation logic computes depth from the one or more regions of interest of the raw image.