The present application discloses a method of and apparatus for interference measurement in coordinated multipoint transmission so as to enable a user equipment to report corresponding channel state information accurately with respect to different interference sources. In the method according to an embodiment of the invention, the network side configures a user equipment with a plurality of sets of REs for interference measurement with respect to different interference sources and instructs the user equipment to select a set of REs for interference measurement adapted to an actual application environment to perform interference measurement, and as such in CoMP transmission, the user equipment can report channel state information with respect to the different interference sources accurately according to a network environment, so that the network side can gain timely knowledge of a change in network environment, thus accommodating a demand of CoMP transmission and further improving the performance of the system.