Real-time selection of interference cancellation schemes based on transmission parameters and amount of resource overlap between the desired payload and the interfering payload. Codeword level interference cancellation may be performed where the signal quality of the interfering signal indicates that the interfering payload will be decoded correctly. When performed, codeword level interference cancellation may be monitored to determine if decoding the interfering payload is converging. Other interference cancellation schemes may be selected based on the signal quality of the interfering signal or non-converging decode of the interfering payload. The number of iterations for iterative decoding in codeword level interference cancellation may be dynamically selected. The decoder output (e.g., soft bits) may be used to perform interference cancellations before the decoder is fully converged. Iterative decoding may be performed in multiple passes and soft decision output form one pass may be used to initialize the decoder for a subsequent pass.