A multi-domain decision manager facilitates software development of a software application across knowledge domains, based on relationships between a first knowledge domain and a second knowledge domain. The multi-domain decision manager includes an assessment engine configured to construct a first assessment as an instantiation of a first knowledge base model of the first knowledge domain, and a second assessment as an instantiation of a second knowledge base model of the second knowledge domain. A relationship engine may be configured to characterize relationships between the first assessment and the second assessment, wherein the relationships characterize a likelihood that inclusion of a first selectable assessment option of the first assessment is associated with inclusion of a second selectable assessment option of the second assessment. A relationship analyzer may be configured to provide a relationship analysis characterizing a cumulative impact of the relationships on the first assessment and the second assessment.