Invention Grant
- Patent Title: Flagellar and needle complex (injectosome) loop as anti bacterial drug target
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Application No.: US14770708Application Date: 2014-02-27
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Publication No.: US09809595B2Publication Date: 2017-11-07
- Inventor: Fadel Alexis Samatey , Vladimir A Meshcheryakov , Hideyuki Matsunami , Akio Kitao
- Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Applicant Address: JP Okinawa
- Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Current Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Current Assignee Address: JP Okinawa
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- International Application: PCT/JP2014/056082 WO 20140227
- International Announcement: WO2014/133197 WO 20140904
- Main IPC: C07D473/08
- IPC: C07D473/08 ; A61K31/505 ; A61K31/522 ; C12Q1/02 ; C12Q1/18 ; C07D239/49
Abstract:
The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
Public/Granted literature
- US20160002239A1 FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET Public/Granted day:2016-01-07
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