- 专利标题: Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
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申请号: US14929177申请日: 2015-10-30
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公开(公告)号: US09816080B2公开(公告)日: 2017-11-14
- 发明人: Quan Lu , Qiyu Wang , Stanley N. Cohen
- 申请人: President and Fellows of Harvard College , The Board of Trustees of the Leland Stanford Junior University
- 申请人地址: US MA Cambridge US CA Stanford
- 专利权人: President and Fellows of Harvard College,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人: President and Fellows of Harvard College,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址: US MA Cambridge US CA Stanford
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 主分类号: C07K14/47
- IPC分类号: C07K14/47 ; C07K19/00 ; C12N9/16 ; C12N15/87 ; C12N9/22 ; C07K7/06 ; C12N9/00 ; A61K9/127
摘要:
Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
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