A thermal protection circuit which relates to the field of electronic technologies can detect temperature of multiple locations simultaneously and adjust a preset threshold flexibly, thereby improving system reliability. The thermal protection circuit includes: at least one temperature sensor, a detection circuit, an execution circuit, a self-locking and triggering circuit, a protective temperature regulation circuit, and a power supply circuit. The at least one temperature sensor converts a temperature signal into an electrical signal and sends the electrical signal to the detection circuit; the detection circuit detects whether temperature reaches the preset threshold, and sends a turn-off signal to the execution circuit if the temperature reaches the preset threshold; the execution circuit cuts off power supply to the system; and the self-locking and triggering circuit maintains, a power-off state of the system until a power switch is triggered.