Technologies for location-dependent wireless speaker configuration include a mobile computing device wirelessly coupled to a plurality of speakers. The mobile computing device is configured to determine a location of and assign a location indicator to each of the speakers based on the determined locations. The location indicator identifies a location of each speaker relative to the other speakers such that the mobile computing device can generate an audio stream for each of the speakers based on the assigned location indicator and transmit each of the generated audio streams to a corresponding one of the speakers. Other embodiments are described and claimed herein.