A method to identify a targeted object based on eye tracking and gesture recognition. The method is enacted in a compute system controlled by a user and operatively coupled to a machine vision system. In this method, the compute system receives, from the machine vision system, video imaging a head and pointer of the user. Based on the video, the compute system computes a geometric line of sight of the user, which is partly occluded by the pointer. Then, with reference to position data for one or more objects, the compute system identifies the targeted object, situated along the geometric line of sight.