Described is a system and method for utilizing unmanned aerial vehicles (“UAV”) to facilitate delivery of ordered items to user specified delivery destinations. In one implementation, the UAV may be configured as a one-way UAV that is designed to transport ordered items to the user specified delivery destination but not return to a materials handling facility under its own power. Instead, the one-way UAV may remain at the delivery destination for later retrieval by a retrieval unit (e.g., truck).