- 专利标题： Fused pyrimidines as inhibitors of P97 complex
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申请号： US15112659申请日： 2015-01-19
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公开(公告)号： US09828363B2公开(公告)日： 2017-11-28
- 发明人: Han-Jie Zhou , David Wustrow
- 申请人： Cleave Biosciences, Inc.
- 申请人地址： US CA Burlingame
- 专利权人： Cleave Biosciences, Inc.
- 当前专利权人： Cleave Biosciences, Inc.
- 当前专利权人地址： US CA Burlingame
- 代理机构： Schwegman Lundberg & Woessner, P.A.
- 国际申请： PCT/US2015/011921 WO 20150119
- 国际公布： WO2015/109285 WO 20150723
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D471/04 ; C07D491/048 ; C07D491/052
摘要：
The present invention is directed to certain fused pyrimidines having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion partner; having an amino benzyl or substituted amino benzyl group at the 4 position of the pyrimidine ring; and a 5:6 heterobicyclo ring with at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for treatment of cancer by inhibition of the p97 complex.
公开/授权文献
- US20160332990A1 FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX 公开/授权日：2016-11-17
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