Invention Grant
- Patent Title: Systems and methods of compensation for chromatography column volume variations
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Application No.: US14898272Application Date: 2014-06-17
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Publication No.: US09829470B2Publication Date: 2017-11-28
- Inventor: Geoff C. Gerhardt , Martin Gilar , Bernard Bunner
- Applicant: Waters Technologies Corporation
- Applicant Address: US MA Milford
- Assignee: WATERS TECHNOLOGIES CORPORATION
- Current Assignee: WATERS TECHNOLOGIES CORPORATION
- Current Assignee Address: US MA Milford
- Agency: Schmeiser, Olsen & Watts LLP
- International Application: PCT/US2014/042626 WO 20140617
- International Announcement: WO2014/204893 WO 20141224
- Main IPC: G01N30/20
- IPC: G01N30/20 ; G01N30/86 ; G01N30/60 ; G01N30/02

Abstract:
Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.
Public/Granted literature
- US20160139095A1 SYSTEMS AND METHODS OF COMPENSATION FOR CHROMATOGRAPHY COLUMN VOLUME VARIATIONS Public/Granted day:2016-05-19
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