Invention Grant
- Patent Title: Effective method for specific gene silencing using artificial small RNA
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Application No.: US14855612Application Date: 2015-09-16
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Publication No.: US09834768B2Publication Date: 2017-12-05
- Inventor: Younghoon Lee , Geunu Bak , Hongmarn Park , Jee Soo Choi , Won Kyeong Kim , Shinae Suk , Ji Young Lee , Yeongseong Yoon
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Lex IP Meister, PLLC
- Priority: KR10-2014-0196025 20141231; KR10-2015-0002221 20150107
- Main IPC: C07H21/02
- IPC: C07H21/02 ; G01N33/554 ; C12N15/113
Abstract:
A nucleic acid molecule comprising a stem-loop structure, a nucleic acid complex comprising the nucleic acid molecule, a composition for delivering a target recognition sequence, and the composition comprising the nucleic acid complex. An artificial small ribonucleic acid of the stem-loop structure stably maintains single-strandedness of a target recognition sequence which interacts with a nucleic acid of interest for a gene of interest of a prokaryote, thereby providing a nucleic acid complex for effective silencing of the gene of interest.
Public/Granted literature
- US20160186169A1 Effective method for specific gene silencing using artificial small RNA Public/Granted day:2016-06-30
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