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公开(公告)号：US09834768B2
公开(公告)日：2017-12-05
申请号：US14855612
申请日：2015-09-16
Inventor： Younghoon Lee , Geunu Bak , Hongmarn Park , Jee Soo Choi , Won Kyeong Kim , Shinae Suk , Ji Young Lee , Yeongseong Yoon
IPC: C07H21/02 , G01N33/554 , C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/531 , C12N2330/51
Abstract: A nucleic acid molecule comprising a stem-loop structure, a nucleic acid complex comprising the nucleic acid molecule, a composition for delivering a target recognition sequence, and the composition comprising the nucleic acid complex. An artificial small ribonucleic acid of the stem-loop structure stably maintains single-strandedness of a target recognition sequence which interacts with a nucleic acid of interest for a gene of interest of a prokaryote, thereby providing a nucleic acid complex for effective silencing of the gene of interest.
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2.发明申请公开(公告)号：US20160186169A1
公开(公告)日：2016-06-30
申请号：US14855612
申请日：2015-09-16
Inventor： Younghoon LEE , Geunu Bak , Hongmarn Park , Jee Soo Choi , Won Kyeong Kim , Shinae Suk , Ji Young Lee , Yeongseong Yoon
IPC: C12N15/113 , C12N15/70
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/531 , C12N2330/51
Abstract: A nucleic acid molecule comprising a stem-loop structure, a nucleic acid complex comprising the nucleic acid molecule, a composition for delivering a target recognition sequence, and the composition comprising the nucleic acid complex. An artificial small ribonucleic acid of the stem-loop structure stably maintains single-strandedness of a target recognition sequence which interacts with a nucleic acid of interest for a gene of interest of a prokaryote, thereby providing a nucleic acid complex for effective silencing of the gene of interest.
Abstract translation: 包含茎 - 环结构的核酸分子，包含核酸分子的核酸复合物，用于递送靶识别序列的组合物和包含核酸复合物的组合物。 茎 - 环结构的人造小核糖核酸稳定地维持目标识别序列的单链，其与原核生物感兴趣的基因的目的核酸相互作用，从而提供用于有效沉默基因的核酸复合物 出于兴趣。
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