Optical transmission systems and methods are disclosed that utilize a QSM optical fiber with a large effective area and that supports only two modes, namely the fundamental mode and one higher-order mode. The optical transmission system includes a transmitter and a receiver optically coupled by an optical fiber link that includes at least one section of the QSM optical fiber. Transmission over optical fiber link gives rise to MPI, which is mitigated using a digital signal processor. The QSM optical fiber is designed to have an amount of DMA that allows for the digital signal processor to have reduced complexity as reflected by a reduced number of filter taps as compared to if the DMA were zero.