A method of manufacturing a plurality of orthopedic implant components is provided. The method includes providing a design for a first implant component having at least one dimension that is based on patient-specific information and a design for a second implant component having at least one dimension that is based on patient specific information. A build plan is created that includes a position and orientation for at least each of the first and second implant components within a build chamber of a solid freeform fabrication machine and with respect to a platform of the build chamber. The implants included in the build plan are produced by executing a build run of the solid freeform fabrication machine based on the build plan, wherein the plurality of implant components are positioned and oriented in an interleaved build configuration according to the build plan.