- 专利标题： Peptide having cancer selective translocation function and use thereof
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申请号： US15234396申请日： 2016-08-11
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公开(公告)号： US09849190B2公开(公告)日： 2017-12-26
- 发明人: Yoon Jeong Park , Chong-Pyoung Chung , Jin Sook Suh , Yoon Jung Choi
- 申请人： SNU R&DB FOUNDATION , Nano Intelligent Biomedical Engineering Corporation Co. Ltd
- 申请人地址： KR Seoul KR Seoul
- 专利权人： SNU R&DB FOUNDATION,NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO, LTD.
- 当前专利权人： SNU R&DB FOUNDATION,NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO, LTD.
- 当前专利权人地址： KR Seoul KR Seoul
- 代理机构： Hultquist, PLLC
- 代理商 Steven J. Hultquist
- 优先权： KR10-2012-0103620 20120918
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K47/64 ; C07K14/47 ; C07K7/08 ; C12Q1/26 ; C12Q1/58 ; C12Q1/66 ; A61K47/48 ; G01N33/574 ; A61K31/704 ; A61K49/00
摘要：
A method of treating breast cancer is described, in which a peptide having cancer selective translocation function-doxoribicin conjugate is administered. The conjugate includes doxorubicin chemically linked to the N-terminus or C-terminus of a VEGF-binding protein transduction domain (VPTD) peptide represented as SEQ ID NO: 1, wherein the VPTD peptide and doxorubicin are linked to each other by a disulfide bond, and wherein the VPTD peptide binds specifically to vascular endothelial growth factor (VEGF) in tumor cells or tumor tissues.
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