- 专利标题： Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins
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申请号： US14482659申请日： 2014-09-10
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公开(公告)号： US09856233B2公开(公告)日： 2018-01-02
- 发明人: Jef De Brabander , Jerry W. Shay , Wentian Wang
- 申请人： Jef De Brabander , Jerry W. Shay , Wentian Wang
- 申请人地址： US TX Austin
- 专利权人： Board of Regents of the University of Texas System
- 当前专利权人： Board of Regents of the University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： McCarter & English LLP
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D405/14 ; C07D471/08 ; C07D401/14 ; C07D413/14 ; C07D417/14 ; C07D211/96 ; C12N5/071
摘要：
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic Epithelial Cell (HCEC) model, and pharmaceutical compositions comprising at least one of the small molecule anti-cancer compounds and a pharmaceutically acceptable carrier.