Transmission schemes that can flexibly achieve the desired spatial multiplexing order, spatial diversity order, and channel estimation overhead order are described. For data transmission, the assigned subcarriers and spatial multiplexing order (M) for a receiver are determined, where M≧1. For each assigned subcarrier, M virtual antennas are selected from among V virtual antennas formed with V columns of an orthonormal matrix, where V≧M. V may be selected to achieve the desired spatial diversity order and channel estimation overhead order. Output symbols are mapped to the M virtual antennas selected for each assigned subcarrier by applying the orthonormal matrix. Pilot symbols are also mapped to the V virtual antennas. The mapped symbols are provided for transmission from T transmit antennas, where T≧V. Transmission symbols are generated for the mapped symbols, e.g., based on OFDM or SC-FDMA. Different cyclic delays may be applied for the T transmit antennas to improve diversity.