Invention Grant
- Patent Title: Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and MRI T1 contrast agents using the same
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Application No.: US13814036Application Date: 2011-08-05
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Publication No.: US09861712B2Publication Date: 2018-01-09
- Inventor: Taeg Hwan Hyeon , Byung Hyo Kim , No Hyun Lee , Eung Gyu Kim , Bong Sik Jeon , Eun Byul Kwon , Ju Young Park , Wan Jae Myeong
- Applicant: Taeg Hwan Hyeon , Byung Hyo Kim , No Hyun Lee , Eung Gyu Kim , Bong Sik Jeon , Eun Byul Kwon , Ju Young Park , Wan Jae Myeong
- Applicant Address: KR Seoul
- Assignee: Hanwha Chemical Corporation
- Current Assignee: Hanwha Chemical Corporation
- Current Assignee Address: KR Seoul
- Agency: The Webb Law Firm
- Priority: KR10-2010-0075523 20100805; KR10-2011-0077534 20110803
- International Application: PCT/KR2011/005746 WO 20110805
- International Announcement: WO2012/018240 WO 20120209
- Main IPC: A61K49/18
- IPC: A61K49/18 ; A61K49/10 ; B82Y5/00

Abstract:
Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.
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