公开(公告)号：US20130164222A1

公开(公告)日：2013-06-27

申请号：US13814036

申请日：2011-08-05

申请人： Taeg Hwan Hyeon ,  Byung Hyo Kim ,  No Hyun Lee ,  Eung Gyu Kim ,  Bong Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

发明人： Taeg Hwan Hyeon ,  Byung Hyo Kim ,  No Hyun Lee ,  Eung Gyu Kim ,  Bong Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

IPC分类号： A61K49/10

CPC分类号： A61K49/1839 ,  A61K49/10 ,  A61K49/1836 ,  A61K49/1842 ,  A61K49/1845 ,  A61K49/186 ,  B82Y5/00 ,  Y10S977/811 ,  Y10S977/882 ,  Y10S977/93 ,  Y10T428/2982

摘要： Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.

摘要翻译： 提供了一种基于氧化铁基顺磁性或伪顺磁性纳米颗粒的制备方法，由其制备的基于氧化铁的纳米颗粒，以及包含其的T1对比剂。 更具体地，本公开描述了一种制备基于由油酸铁配合物，基于氧化铁的顺磁性或由其制备的假顺磁性纳米颗粒的热分解而具有4nm或更小的极小且均匀尺寸的氧化铁纳米颗粒的方法， 和包含基于氧化铁的顺磁性或伪顺磁性纳米颗粒的T1造影剂。

公开(公告)号：US09861712B2

公开(公告)日：2018-01-09

申请号：US13814036

申请日：2011-08-05

申请人： Taeg Hwan Hyeon ,  Byung Hyo Kim ,  No Hyun Lee ,  Eung Gyu Kim ,  Bong Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

发明人： Taeg Hwan Hyeon ,  Byung Hyo Kim ,  No Hyun Lee ,  Eung Gyu Kim ,  Bong Sik Jeon ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

IPC分类号： A61K49/18 ,  A61K49/10 ,  B82Y5/00

CPC分类号： A61K49/1839 ,  A61K49/10 ,  A61K49/1836 ,  A61K49/1842 ,  A61K49/1845 ,  A61K49/186 ,  B82Y5/00 ,  Y10S977/811 ,  Y10S977/882 ,  Y10S977/93 ,  Y10T428/2982

摘要： Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.