发明授权
- 专利标题： Method for in-vitro preparation of double-layered virus-like particles of rotavirus
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申请号： US14429586申请日： 2013-06-24
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公开(公告)号： US09862933B2公开(公告)日： 2018-01-09
- 发明人: Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
- 申请人： Xiamen University , Xiamen Innovax Biotech Co., Ltd.
- 申请人地址： CN Xiamen, Fujian CN Xiamen, Fujian
- 专利权人： Xiamen University,Xiamen Innovax Biotech Co., Ltd.
- 当前专利权人： Xiamen University,Xiamen Innovax Biotech Co., Ltd.
- 当前专利权人地址： CN Xiamen, Fujian CN Xiamen, Fujian
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Thomas A. Wootton, Esq.; Jonathan P. O'Obrien
- 优先权： CN201210350365 20120920
- 国际申请： PCT/CN2013/077736 WO 20130624
- 国际公布： WO2014/044067 WO 20140327
- 主分类号： C12N7/04
- IPC分类号： C12N7/04 ; C12N7/00 ; A61K38/16 ; A61K39/00
摘要：
The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
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