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公开(公告)号：US11339194B2
公开(公告)日：2022-05-24
申请号：US16901410
申请日：2020-06-15
发明人： Shengxiang Ge , Tingdong Li , Lianzhi Jia , Yijian Li , Miaoge Xue , Yuanjun Zeng , Huirong Pan , Jun Zhang , Ningshao Xia
IPC分类号： C07K14/005 , A61K31/14 , A61P1/12 , A61K39/12 , A61K39/15 , A61P31/14 , A61P1/00 , A61P29/00 , C12N7/00 , A61K39/00
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
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公开(公告)号：US20200308233A1
公开(公告)日：2020-10-01
申请号：US16901410
申请日：2020-06-15
发明人： Shengxiang Ge , Tingdong Li , Lianzhi Jia , Yijian Li , Miaoge Xue , Yuanjun Zeng , Huirong Pan , Jun Zhang , Ningshao Xia
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
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3.发明申请Method for In-Vitro Preparation of Double-Layered Virus-Like Particles of Rotavirus 有权轮状病毒双层病毒样颗粒体外制备方法公开(公告)号：US20150252334A1
公开(公告)日：2015-09-10
申请号：US14429586
申请日：2013-06-24
发明人： Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K38/162 , A61K39/00 , C12N7/04 , C12N2720/12322 , C12N2720/12323 , C12N2720/12333 , C12N2720/12334 , C12N2720/12352
摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
摘要翻译： 本发明涉及一种体外制备轮状病毒双层病毒样颗粒的方法。 该方法包括以下步骤：从裂解上清液中纯化轮状病毒VP6蛋白，以及体外组装由VP2蛋白和VP6蛋白组成的双层病毒样颗粒，其中蛋白质和病毒样颗粒可用于预防或 减少轮状病毒感染引起的临床症状。
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公开(公告)号：US10723767B2
公开(公告)日：2020-07-28
申请号：US15575140
申请日：2016-05-20
发明人： Shengxiang Ge , Tingdong Li , Lianzhi Jia , Yijian Li , Miaoge Xue , Yuanjun Zeng , Huirong Pan , Jun Zhang , Ningshao Xia
IPC分类号： C07K14/005 , C12N7/00 , A61K39/12 , A61K39/15 , A61P31/14 , A61P1/12 , A61P1/00 , A61P29/00 , A61K39/00
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
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公开(公告)号：US09862933B2
公开(公告)日：2018-01-09
申请号：US14429586
申请日：2013-06-24
发明人： Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
CPC分类号： C12N7/00 , A61K38/162 , A61K39/00 , C12N7/04 , C12N2720/12322 , C12N2720/12323 , C12N2720/12333 , C12N2720/12334 , C12N2720/12352
摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
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6.发明授权公开(公告)号：US10309964B2
公开(公告)日：2019-06-04
申请号：US15549443
申请日：2016-01-26
申请人： XIAMEN UNIVERSITY
发明人： Shengxiang Ge , Jinjie Li , Xi Huang , Tingdong Li , Jun Zhang , Ningshao Xia
IPC分类号： A61K39/42 , G01N33/53 , G01N33/543 , G01N33/569
摘要： The invention belongs to the fields of medicine and immunology, particularly, the field of immunological diagnosis. In particular, the invention discloses a method for assessing whether a subject is at risk of developing human cytomegalovirus (HCMV) active infection and a kit therefore. The method comprises the steps of: (1) determining the level of an antibody against a HCMV protein in a body fluid sample from the subject; and (2) comparing the level with a predetermined reference value, wherein if the level is below the predetermined reference value, the subject is determined to be at risk of developing HCMV active infection. In addition, the invention also discloses a method for screening a candidate drug which is capable of improving the ability of a subject to resist human cytomegalovirus (HCMV) active infection, and a kit therefore.
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