- 专利标题: Method of quenching singlet and triplet excited states of pigments, such as porphyrin compounds, particularly protoporphyrin IX, with conjugated fused tricyclic compounds have electron withdrawing groups, to reduce generation of reactive oxygen species, particularly singlet oxygen
-
申请号: US13805168申请日: 2012-12-03
-
公开(公告)号: US09867800B2公开(公告)日: 2018-01-16
- 发明人: Craig A. Bonda , Shengkui Hu
- 申请人: HALLSTAR INNOVATIONS CORP.
- 申请人地址: US IL Chicago
- 专利权人: Hallstar Innovations Corp.
- 当前专利权人: Hallstar Innovations Corp.
- 当前专利权人地址: US IL Chicago
- 代理机构: Baker & McKenzie LLP
- 国际申请: PCT/US2012/067519 WO 20121203
- 国际公布: WO2014/025370 WO 20140213
- 主分类号: A61K31/277
- IPC分类号: A61K31/277 ; A61K8/40 ; A61K8/49 ; A61Q17/04 ; A61K31/382 ; C07D311/82 ; C07D335/12 ; A61K8/46 ; A61K31/216 ; A61K31/352 ; C07C325/02 ; C07C255/41 ; A61K45/06 ; C09B11/28 ; C09B23/01 ; C09B23/04 ; C09B23/10
摘要:
A method of quenching excited state energy from a pigment that has been excited by absorption of light having a wavelength in the wavelength range of 290-800 nm, comprising reacting a pigment with a conjugated fused tricyclic compound having electron withdrawing groups: of Formula (II) or a salt thereof: wherein: A is selected from the group consisting of O, S, C═O, C═S, and B1, B2, D1, and D2 are each independently selected from the group consisting of F, Cl, Br, I, CF3, CCl3, NR33+, NO2, CN, C(═O)R4, C(═O)OR1, SO2R5, aryl, and —C═CHR6; each m independently is 0, 1, 2, 3, or 4; n is 0 or 1; each R1 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl; R2 is selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, and aryl; each R3 is independently selected from the group consisting of H and C1-C6 alkyl; each R4 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl; each R5 is independently selected from the group consisting of H, O−, OH, NH2, and Cl; and, each R6 is independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl.
信息查询