- 专利标题： Compounds and compositions for intracellular delivery of therapeutic agents
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申请号： US15476253申请日： 2017-03-31
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公开(公告)号： US09868691B2公开(公告)日： 2018-01-16
- 发明人: Kerry E. Benenato
- 申请人： MODERNATX, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： ModernaTX, Inc.
- 当前专利权人： ModernaTX, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Cooley LLP
- 代理商 Heidi A. Erlacher; Christine C. Pemberton
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K48/00 ; C07C229/12 ; A61K9/127 ; C07C271/20 ; C07C279/12 ; C07C279/28 ; C07C279/32 ; C07D233/72 ; C07D249/04 ; C07D263/20 ; C07D265/33 ; C07D271/06 ; C07D271/10 ; C07D207/27 ; C07D277/38 ; C07C275/14 ; C07C279/24 ; C07C311/05 ; C07C229/16 ; C07C335/08 ; C07C233/36 ; C07C235/10 ; C07C255/24 ; C07F9/09 ; A61K9/16 ; A61K38/18 ; C07K14/505 ; A61K9/00 ; A61K47/54 ; A61K47/69
摘要：
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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