Invention Grant
- Patent Title: Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors
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Application No.: US14333375Application Date: 2014-07-16
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Publication No.: US09873740B2Publication Date: 2018-01-23
- Inventor: Jane Grogan , Robert J. Johnston , Bryan Irving , Jason Hackney , Xin Yu , Dan Eaton , Kristin Bowles , Laetitia Comps-Agrar
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A01K67/027 ; C07K14/705 ; A61K45/06 ; C07K16/30 ; A61K39/00
Abstract:
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
Public/Granted literature
- US20150216970A1 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS Public/Granted day:2015-08-06
Information query
