Invention Grant
- Patent Title: Method for producing heterocyclic compound
-
Application No.: US15301525Application Date: 2015-04-09
-
Publication No.: US09878981B2Publication Date: 2018-01-30
- Inventor: Hironori Yamashita , Kazuhiro Miwa
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka
- Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2014-080984 20140410
- International Application: PCT/JP2015/061075 WO 20150409
- International Announcement: WO2015/156346 WO 20151015
- Main IPC: C07D211/60
- IPC: C07D211/60 ; C07C231/02 ; C07D401/06

Abstract:
Provided is a production method of a synthetic intermediate for a heterocyclic compound having a renin inhibitory activity and useful as a prophylactic or therapeutic drug for diabetic nephropathy, hypertension and the like. A production method of a compound represented by the formula (III-1a), the formula (III-1b), the formula (III-1c) and/or the formula (III-1d); wherein each symbol is as described in DESCRIPTION, or a salt thereof, including reacting a compound represented by the formula (Ia) or (Ib): wherein each symbol is as described in DESCRIPTION, or a salt thereof with a compound represented by the formula (II): wherein each symbol is as described in DESCRIPTION, or a salt thereof, in the presence of an aluminum compound and a chiral amine compound.
Public/Granted literature
- US20170121286A1 METHOD FOR PRODUCING HETEROCYCLIC COMPOUND Public/Granted day:2017-05-04
Information query