A system and method for dynamically validating uplink messages during flight are provided. The system comprises at least one processing unit in an aircraft, and at least one communication device in the aircraft that is operatively connected to the processing unit. The communication device is configured to receive uplink messages from a ground air traffic control (ATC) center, and transmit downlink messages to the ground ATC center. The system also includes a human machine interface (HMI) in the aircraft that is operatively connected to the processing unit. The HMI is configured to receive input from a user and display information to the user. One or more data sources that provide dynamic information are in operative communication with the processing unit. The processing unit is configured to determine whether an ATC uplink message is acceptable based on analysis of the dynamic information from the one or more data sources.