A differential amplifier has an inherent offset voltage. In many circuit applications, such as with a voltage to current converter circuit, it is important to nullify that offset voltage. A calibration circuit is provided to configured the differential amplifier to operate as a comparator with a common voltage applied to both inputs. The logic state of the output of the amplifier indicates whether the offset voltage is positive or negative. In response thereto, a trim current with a progressively increasing magnitude is injected into the amplifier and the amplifier output is monitored to detect a change in logic state. The magnitude of the trim current at the point where the logic state changes is the magnitude of trim current needed to nullify the voltage offset.