发明授权
- 专利标题: Thiol compounds and the use thereof for the synthesis of modified oligonucleotides
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申请号: US14390747申请日: 2013-04-04
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公开(公告)号: US09896473B2公开(公告)日: 2018-02-20
- 发明人: François Morvan , Albert Meyer , Jean-Jacques Vasseur , Julie Mayen , Carole Chaix , Carole Farre , Chantal Fournier-Wirth , Jean-François Cantaloube , Myriam Lereau
- 申请人: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE MONTPELLIER 1 , ETABLISSEMENT FRANÇAIS DU SANG , UNIVERSITE CLAUSE BERNARD LYON 1
- 申请人地址: FR Saint Denis FR Paris
- 专利权人: Etablissement Francais du Sang,Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人: Etablissement Francais du Sang,Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人地址: FR Saint Denis FR Paris
- 代理机构: Marsh Fischmann & Breyfogle LLP
- 优先权: FR1253121 20120404
- 国际申请: PCT/EP2013/057122 WO 20130404
- 国际公布: WO2013/150106 WO 20131010
- 主分类号: C07H21/04
- IPC分类号: C07H21/04 ; C07F9/24 ; C07C323/52 ; C08F257/02 ; C12N15/11
摘要:
The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.
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