公开(公告)号：US11078229B2

公开(公告)日：2021-08-03

申请号：US15862485

申请日：2018-01-04

申请人： Etablissement Français du Sang ,  Centre National de la Recherche Scientifique (CNRS)

发明人： François Morvan ,  Albert Meyer ,  Jean-Jacques Vasseur ,  Julie Mayen ,  Carole Chaix ,  Carole Farre ,  Chantal Fournier-Wirth ,  Jean-François Cantaloube ,  Myriam Lereau

IPC分类号： C07H21/04 ,  C12N15/11 ,  C07F9/24 ,  C07C323/52 ,  C08F257/02

摘要： The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

公开(公告)号：US20200340913A1

公开(公告)日：2020-10-29

申请号：US16768366

申请日：2018-11-30

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RESEARCHE MÉDECALE) ,  UNIVERSITÉ PARIS EST CRÉTEIL VAL DE MARNE ,  ETABLISSEMENT FRANÇAIS DU SANG ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Laurent KIGER ,  Michael MARDEN ,  Pablo BARTOLUCCI ,  France PIRENNE

IPC分类号： G01N21/31 ,  G01N33/48

摘要： The aim of the present invention is to propose a novel method for spectral study of a biological fluid from an absorption spectrum of a sample of the biological fluid. The inventors have made an original use of spectroscopy in order to accurately determine the protein content of a biological sample, in particular for oxyhaemoglobin, methaemoglobin, bilirubin and the haem bound to serum albumin. Such a method can be used in a variety of applications concerning haem- or haemoprotein- related diseases, in particular diagnostic methods, treatment follow-up methods, methods for determining biomarkers or screening methods. Such a method is also advantageous for qualifying blood bags.

公开(公告)号：US20140308261A1

公开(公告)日：2014-10-16

申请号：US14359442

申请日：2012-11-21

申请人： Etablissement Français du Sang

发明人： Assia El Jaafari ,  Dominique Rigal ,  Diane Scott

IPC分类号： C07K7/08

CPC分类号： C07K7/08 ,  C07K14/47 ,  C07K14/70539

摘要： This invention concerns HY epitopic polypeptides specifically presented by the HLA-DR7 molecule, a method for preparing these epitopic polypeptides, isolated T-lymphocytes capable of specifically recognizing an epitope from these polypeptides or from a polypeptide comprising the complete sequence of the protein encoded by the RPS4Y gene and presented by the HLA-DR7 molecule expressed on the surface of antigen-presenting cells, a method for preparing these T-lymphocytes, as well as the use of these epitopic polypeptides and these T-lymphocytes as medicaments, in particular for the treatment of cancers of immune cells.

摘要翻译： 本发明涉及由HLA-DR7分子特异性表达的HY表位多肽，制备这些表位多肽的方法，能够特异性识别来自这些多肽的表位的分离的T淋巴细胞，或包含由该多肽编码的蛋白质的完整序列的多肽 RPS4Y基因并由抗原呈递细胞表面上表达的HLA-DR7分子呈递，制备这些T淋巴细胞的方法，以及这些表位多肽和这些T淋巴细胞作为药物的用途，特别是用于 治疗免疫细胞癌。

公开(公告)号：US20240319209A1

公开(公告)日：2024-09-26

申请号：US18578165

申请日：2022-07-15

申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) ,  ETABLISSEMENT FRANÇAIS DU SANG (EFS) ,  UNIVERSITÉ PARIS-EST CRÉTEIL VAL DE MARNE

发明人： Véronique BAUDIN-CREUZA ,  Frédéric GALACTEROS ,  Corinne VASSEUR

IPC分类号： G01N33/68 ,  A61K31/17 ,  A61P7/06

CPC分类号： G01N33/6893 ,  A61K31/17 ,  A61P7/06 ,  G01N2470/04 ,  G01N2800/22 ,  G01N2800/52

摘要： The Alpha haemoglobin-stabilising protein (AHSP) is a key chaperone molecule synthesised in red blood cell (RBC) precursors. In this study, the inventors have developed a sandwich ELISA method which allows the quantification of AHSP protein in RBCs of normal subjects and in sickle cell anaemia (SCA) patients treated or untreated by hydroxycarbamide. AHSP was significantly more abundant in untreated SCA patients than in controls (p

公开(公告)号：US11662303B2

公开(公告)日：2023-05-30

申请号：US16768366

申请日：2018-11-30

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ PARIS EST CRÉTEIL VAL DE MARNE ,  ETABLISSEMENT FRANÇAIS DU SANG ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Laurent Kiger ,  Michael Marden ,  Pablo Bartolucci ,  France Pirenne

IPC分类号： G01N21/31 ,  G01N33/48

CPC分类号： G01N21/31 ,  G01N33/48

摘要： The aim of the present invention is to propose a novel method for spectral study of a biological fluid from an absorption spectrum of a sample of the biological fluid. The inventors have made an original use of spectroscopy in order to accurately determine the protein content of a biological sample, in particular for oxyhaemoglobin, methaemoglobin, bilirubin and the haem bound to serum albumin. Such a method can be used in a variety of applications concerning haem- or haemoprotein- related diseases, in particular diagnostic methods, treatment follow-up methods, methods for determining biomarkers or screening methods. Such a method is also advantageous for qualifying blood bags.

公开(公告)号：US11458118B2

公开(公告)日：2022-10-04

申请号：US16606236

申请日：2018-04-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE BRETAGNE OCCIDENTALE ,  ETABLISSEMENT FRANÇAIS DU SANG (EFS) ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST

发明人： Pascal Trouve ,  Claude Ferec ,  Mathieu Kerbiriou ,  Florentin Huguet

IPC分类号： A61K31/40 ,  A61P11/00 ,  A61K9/00 ,  C12N15/113

摘要： Activating transcription factor 6 (ATF6) is involved in cystic fibrosis transmembrane conductance regulator (CFTR) repression and understanding this inhibitory mechanism is of great interest to develop a therapeutic approach based on UPR regulation. Using site-1 protease (S1P) inhibitor (e.g. PF-429242) the inventors showed that both membrane localization and function of F508del-CFTR are partially restored. Accordingly, the present invention relates to a method of treating a disease associated with reduced CFTR function in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a S1P inhibitor.

公开(公告)号：US20220023325A1

公开(公告)日：2022-01-27

申请号：US16472754

申请日：2017-12-22

申请人： Etablissement Français du Sang ,  Centre national de la recherche scientifique ,  UNIVERSITE PAUL SABATIER TOULOUSE III ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Nicolas ESPAGNOLLE ,  Frédéric DESCHASEAUX ,  Luc SENSEBE ,  Philippe BOURIN

IPC分类号： A61K31/7008 ,  A61P35/00

摘要： The present invention relates to a TLR4 (toll-like receptor 4) specific antagonist for use in the treatment of multiple myeloma in a subject suffering from multiple myeloma, and also to an antitumor pharmaceutical combination comprising (i) a TLR4-specific antagonist and (ii) a chemotherapy agent for simultaneous, separate or sequential use in the treatment of multiple myeloma.

公开(公告)号：US10919018B2

公开(公告)日：2021-02-16

申请号：US16094798

申请日：2017-06-19

申请人： Etablissement Français du Sang

发明人： Medhi Alizadeh ,  Cyrus Mahdjoubi

IPC分类号： B01J19/10 ,  B01F11/02 ,  B06B3/00 ,  C12Q1/6806 ,  G01N1/28 ,  B01L9/06

摘要： A device for the fragmentation of DNA samples. The DNA samples are in solution in a container the device including —a vessel for receiving a liquid, the vessel being configured to produce ultrasonic waves so as to spread ultrasonic waves through the liquid. The device further includes a first support element resting on the vessel, the device further includes a second support element having a passage designed to receive the container. The second support element can be suspended by at least one suspension element forming at least one joint, such that a lower portion of the container can be immersed in the liquid.

公开(公告)号：US20200000878A1

公开(公告)日：2020-01-02

申请号：US16481111

申请日：2017-12-22

申请人： UNIVERSITE TOULOUSE III-PAUL SABATIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ETABLISSEMENT FRANÇAIS DU SANG

发明人： Jean-Philippe COMBIER ,  Anne PREL ,  Frédéric DESCHASEAUX

IPC分类号： A61K38/17 ,  C12Q1/6883 ,  A61P31/14 ,  A61P19/08 ,  A61P11/00 ,  A61P35/00 ,  A61P9/10

摘要： Compositions containing micropeptides capable of modulating the accumulation of miRs involved in certain pathologies, and the use of these micropeptides for treating the certain pathologies. Also, methods of identifying these micropeptides modulating the accumulation of miRs involved in pathologies. Further, nuclei acids encoding those micropeptides that modulate the accumulation of miRs involved in pathologies.

公开(公告)号：US20150232957A1

公开(公告)日：2015-08-20

申请号：US14390748

申请日：2013-04-04

申请人： ETABLISSEMENT FRANÇAIS DU SANG ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE MONTPELLIER 1 ,  UNIVERSITE CLAUDE BERNARD LYON 1

发明人： Chantal Fournier-Wirth ,  Myriam Lereau ,  Jean-François Cantaloube ,  Jean-Jacques Vasseur ,  François Morvan ,  Albert Meyer ,  Julie Mayen ,  Carole Chaix ,  Carole Farre

IPC分类号： C12Q1/70

CPC分类号： C12Q1/707 ,  C07H21/00 ,  C07H21/04 ,  C12Q2600/158

摘要： The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.

摘要翻译： 本发明涉及具有两个或多个硫醇官能团的修饰的寡核苷酸，其可以固定在金表面或接枝表面上，特别是包含至少一个碳 - 碳双键或碳 - 碳三键或卤代乙酰胺 功能，优选马来酰亚胺或丙烯酰胺的功能。 本发明还涉及用于检测生物样品中的核酸的方法，其包括检测经修饰的寡核苷酸与从生物样品扩增的靶核酸之间的杂交的步骤。 本发明更具体地涉及用于检测，基因分型或测序病原生物体，优选病毒的方法。