An interconnection and a method for manufacturing thereof are provided. The interconnection includes a first conductive layer, a dielectric layer, a second conductive layer, an insulation layer, and a plurality of air gaps. The first conductive layer is disposed over a semiconductor substrate. The dielectric layer is disposed over the first conductive layer. The second conductive layer penetrates through the dielectric layer to electrically connect with the first conductive layer. The insulation layer is located between a portion of the dielectric layer and the second conductive layer, and a material of the insulation layer and a material of the dielectric layer are different. The air gaps are located between another portion of the dielectric layer and the second conductive layer.