- 专利标题: Macrocyclic compounds as TRK kinase inhibitors
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申请号: US15632187申请日: 2017-06-23
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公开(公告)号: US09902741B2公开(公告)日: 2018-02-27
- 发明人: Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
- 申请人: Array BioPharma, Inc.
- 申请人地址: US CO Boulder
- 专利权人: Array BioPharma Inc.
- 当前专利权人: Array BioPharma Inc.
- 当前专利权人地址: US CO Boulder
- 代理机构: Fish & Richardson P.C.
- 主分类号: C07D498/22
- IPC分类号: C07D498/22 ; C07D471/22 ; C07D487/22
摘要:
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
公开/授权文献
- US20170283435A1 MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS 公开/授权日:2017-10-05
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