Invention Grant
- Patent Title: Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
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Application No.: US15085164Application Date: 2016-03-30
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Publication No.: US09931323B2Publication Date: 2018-04-03
- Inventor: Jason Burch , Minghua Sun , Xiaojing Wang , Wesley Blackaby , Alastair James Hodges , Andrew Sharpe
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Alston & Bird LLP
- Main IPC: A61K31/427
- IPC: A61K31/427 ; A61K31/4439 ; A61K31/4375 ; A61K45/06 ; C07D417/12 ; C07D405/14 ; A61K31/497 ; A61K31/506 ; C07D417/14 ; C07D471/04 ; C07D493/08

Abstract:
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Public/Granted literature
- US20160213652A1 Cyclic Ether Pyrazol-4-YL-Heterocyclyl-Carboxamide Compounds And Methods Of Use Public/Granted day:2016-07-28
Information query
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