Invention Grant
- Patent Title: Subgroup B recombinant human adenovirus vector, and methods for constructing and for using the same
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Application No.: US15098342Application Date: 2016-04-14
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Publication No.: US09932606B2Publication Date: 2018-04-03
- Inventor: Yaohe Wang , Guozhong Jiang , Hanshi Wong , Fengyu Cao , Nick Lemoine
- Applicant: Beijing Bio-Targeting Therapeutics Technology Inc.
- Applicant Address: CN Beijing
- Assignee: BEIJING BIO-TARGETING THERAPEUTICS TECHNOLOGY INC.
- Current Assignee: BEIJING BIO-TARGETING THERAPEUTICS TECHNOLOGY INC.
- Current Assignee Address: CN Beijing
- Agency: Matthias Scholl, PC
- Agent Matthias Scholl
- Priority: CN201110143385 20110531
- Main IPC: C12N15/64
- IPC: C12N15/64 ; C12N15/86 ; A61K48/00 ; A61P35/00 ; A61K35/761 ; C12N7/00
Abstract:
A method for reconstructing a replication-selective oncolytic adenovirus using a subgroup B recombinant human adenovirus vector Ad11-5EP. The method includes: 1) deleting E1A CR2 gene and/or anti-apoptotic gene E1B 21K that is necessary for viability of an adenovirus in normal cells but not necessary in tumor cells; 2) inserting a tumor-specific promoter to drive the expression of E1A gene; 3) re-directing a cellular tropism of Ad11-5EP according to receptors on a tumor cell surface; or 4) allowing adenovirus to selectively replicate in tumor cells.
Public/Granted literature
- US20160222413A1 SUBGROUP B RECOMBINANT HUMAN ADENOVIRUS VECTOR, AND METHODS FOR CONSTRUCTING AND FOR USING THE SAME Public/Granted day:2016-08-04
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