- Patent Title: Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
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Application No.: US15433536Application Date: 2017-02-15
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Publication No.: US09951058B2Publication Date: 2018-04-24
- Inventor: Young Sik Jung , Soo Bong Han , Chong-Kyo Lee , Hae Soo Kim , Jin Soo Shin , Johan Neyts , Hendrik Jan Thibaut , Yashwardhan Radhamohan Malpani
- Applicant: Korea Research Institute of Chemical Technology , Katholieke Universiteit Leuven K.U. Leuven R & D
- Applicant Address: BE Belgium KR Daejeon-si
- Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D,KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Current Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D,KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Current Assignee Address: BE Belgium KR Daejeon-si
- Agency: Brinks Gilson & Lione
- Priority: KR10-2012-0146081 20121214; KR10-2013-0156409 20131216
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D307/93 ; C07D405/12 ; C07D409/12 ; C07D407/12 ; C07D413/12

Abstract:
The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.
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