A handheld injection device comprising a housing, a piston rod defining a first longitudinal axis and located within the housing, a driver coupled to the piston rod, a dose setting means, which is rotatable about a second longitudinal axis during dose setting, and optionally a power reservoir for driving the driver and/or a release clutch preventing rotation of the driver during dose setting and allowing rotation of the driver during dose dispensing. The first longitudinal axis is spaced from the second longitudinal axis.