Invention Grant
- Patent Title: Antidiabetic bicyclic compounds
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Application No.: US15034189Application Date: 2014-12-01
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Publication No.: US09957219B2Publication Date: 2018-05-01
- Inventor: Thomas Bara , Harry R. Chobanian , Yan Guo , Hubert Josien , Michael Miller , Barbara Pio , Christopher W. Plummer , Cangming Yang , Dong Xiao
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2014/067845 WO 20141201
- International Announcement: WO2015/084692 WO 20150611
- Main IPC: C07C59/72
- IPC: C07C59/72 ; A61K45/06 ; A61K31/192 ; A61K31/404 ; A61K31/435 ; C07D221/04 ; C07D231/12 ; C07D207/333 ; C07D277/42 ; C07D209/12 ; A61K31/277 ; A61K31/381 ; A61K31/415 ; A61K31/4192 ; A61K31/427 ; A61K31/437 ; A61K31/44 ; C07C255/59 ; C07D209/08 ; C07D213/64 ; C07D249/04 ; C07D333/24 ; C07D417/04 ; C07D471/04

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20160280626A1 ANTIDIABETIC BICYCLIC COMPOUNDS Public/Granted day:2016-09-29
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