发明授权
- 专利标题: Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
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申请号: US13391554申请日: 2010-08-20
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公开(公告)号: US09957530B2公开(公告)日: 2018-05-01
- 发明人: John E. McBride , Vineet Rajgarhia , Arthur J. Shaw, IV , Shital A. Tripathi , Elena Brevnova , Nicky Caiazza , Johannes Pieter Van Dijken , Allan C. Froehlich , William Ryan Sillers , James H. Flatt
- 申请人: John E. McBride , Vineet Rajgarhia , Arthur J. Shaw, IV , Shital A. Tripathi , Elena Brevnova , Nicky Caiazza , Johannes Pieter Van Dijken , Allan C. Froehlich , William Ryan Sillers , James H. Flatt
- 申请人地址: HU Budapest
- 专利权人: Lallemand Hungary Liquidity Management LLC
- 当前专利权人: Lallemand Hungary Liquidity Management LLC
- 当前专利权人地址: HU Budapest
- 代理机构: Nutter McClennen & Fish LLP
- 国际申请: PCT/US2010/046172 WO 20100820
- 国际公布: WO2011/022651 WO 20110224
- 主分类号: C12N1/00
- IPC分类号: C12N1/00 ; C12N1/20 ; C12P7/04 ; C12P7/18 ; C12Q1/00 ; C12Q1/68 ; C07H21/04 ; C12P7/36
摘要:
The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.
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