- 专利标题： Sensor for measuring the activity of beta-pancreatic cells or of islets of langerhans, manufacture and use of such a sensor
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申请号： US13521724申请日： 2011-01-12
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公开(公告)号： US09962113B2公开(公告)日： 2018-05-08
- 发明人: Jochen Lang , Bogdan Catargi , Sylvie Renaud , Matthieu Raoux , Gilles Charpentier
- 申请人： Jochen Lang , Bogdan Catargi , Sylvie Renaud , Matthieu Raoux , Gilles Charpentier
- 申请人地址： FR Talence FR Talence FR Paris FR Bordeaux
- 专利权人： UNIVERSITE DE BORDEAUX 1,INSTITUTE POLYTECHNIQUE DE BORDEAUX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE BORDEAUX SEAGALEN
- 当前专利权人： UNIVERSITE DE BORDEAUX 1,INSTITUTE POLYTECHNIQUE DE BORDEAUX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE BORDEAUX SEAGALEN
- 当前专利权人地址： FR Talence FR Talence FR Paris FR Bordeaux
- 代理机构： Womble Bond Dickinson (US) LLP
- 优先权： FR1050202 20100113
- 国际申请： PCT/EP2011/050359 WO 20110112
- 国际公布： WO2011/086105 WO 20110721
- 主分类号： A61B5/04
- IPC分类号： A61B5/04 ; A61M5/172 ; A61B5/145 ; A61B5/00 ; A61M5/142
摘要：
The invention relates to a sensor (2) including: a microelectrode assembly (21); and β-pancreatic cells (23) or islets (230) of Langerhans in culture on the microelectrode assembly (21); characterized in that the microelectrode assembly (21) is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the β-pancreatic cells (23) or the islets of Langerhans (230) upon physiological activation. The invention also relates to the field of devices that can be implantable in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.
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