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183 条记录 (耗时 0.035 秒)

    Occupant protection device comprising safety valve
    1.
    发明授权
    Occupant protection device comprising safety valve 有权
    乘员保护装置包括安全阀

    公开(公告)号：US08585091B2

    公开(公告)日：2013-11-19

    申请号：US13392086

    申请日：2010-08-30

    申请人： Jochen Benz ,  Lars Mast ,  Jochen Lang ,  Christoph Pechhold ,  Robert Fleischmann

    发明人： Jochen Benz ,  Lars Mast ,  Jochen Lang ,  Christoph Pechhold ,  Robert Fleischmann

    IPC分类号： B60R22/46

    CPC分类号： B60R22/4628 ,  B60R21/276 ,  B60R2022/4642 ,  F42B39/20

    摘要： An occupant protection device including a pyrotechnical gas generator and a safety valve operating in a temperature-dependent manner and leading to the outside is connected to the gas generator. A sealing element of the safety valve is formed by a pin that includes a pin head, which is inserted from inside into a hole in a wall of a supply element such that the pin head bears against the inner face of the wall. A pin end, which is located on the outer face of the wall and protrudes outwardly through the hole, is plastically reshaped, so that the cross section of the pin end is larger than the cross section of the hole thereby forming a sealing portion which is larger in cross section than the cross section of the hole.

    摘要翻译： 包括烟火气体发生器和以温度依赖的方式操作并通向外部的安全阀的乘员保护装置连接到气体发生器。 安全阀的密封元件由销构成，该销包括销头，该销头从内部插入到供应元件的壁中的孔中，使得销头抵靠在壁的内表面上。 位于壁的外表面并通过孔向外突出的销端被塑性重塑，使得销端的横截面大于孔的横截面从而形成密封部分，该密封部分是 横截面比孔的横截面大。

    Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, pharmaceutical compositions and therapeutic use
    2.
    发明授权
    Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, pharmaceutical compositions and therapeutic use 有权
    取代的4-苯基四氢异喹啉，其制备方法，药物组合物和治疗用途

    公开(公告)号：US08455515B2

    公开(公告)日：2013-06-04

    申请号：US12046928

    申请日：2008-03-12

    申请人： Hans-Jochen Lang

    发明人： Hans-Jochen Lang

    IPC分类号： C07D217/04 ,  A61K31/472

    CPC分类号： C07D217/14

    摘要： The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds and pharmaceutical compositions comprising them which are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE-3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke. More specifically, the present invention relates to substituted 4-phenyl-tetrahydroisoquinolines defined by the formula I in which R1-R8 are defined herein.

    摘要翻译： 本发明涉及取代的4-苯基四氢异喹啉化合物和包含它们的药物组合物，它们是钠 - 氢交换器（NHE），特别是亚型3（NHE-3）的钠氢交换器的优异抑制剂。 因此，这些化合物可用于治疗肾脏和呼吸系统的各种疾病，例如急性或慢性肾衰竭，肺并发症，胆汁功能障碍，呼吸系统疾病如打鼾或睡眠呼吸暂停和心血管/中枢神经系统疾病，例如 行程。 更具体地，本发明涉及由式I定义的取代的4-苯基 - 四氢异喹啉，其中R 1 -R 8在本文中定义。