Invention Grant
- Patent Title: Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
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Application No.: US15266243Application Date: 2016-09-15
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Publication No.: US09963446B2Publication Date: 2018-05-08
- Inventor: Jason Burch , Huifen Chen , Xiaojing Wang
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Brian L. Buckwalter
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K31/427 ; A61K31/4439 ; A61K31/4709 ; A61K31/497 ; A61K31/4985 ; A61K31/06 ; C07D487/04 ; A61K45/06

Abstract:
Oxepan-2-yl pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Public/Granted literature
- US20170001997A1 OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE Public/Granted day:2017-01-05
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