- 专利标题： Use of sulfonamide inhibitors of Bcl-2 to treat senescence-associated lung conditions such as pulmonary fibrosis and chronic obstructive pulmonary disease
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申请号： US15647688申请日： 2017-07-12
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公开(公告)号： US09980962B2公开(公告)日： 2018-05-29
- 发明人: Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , Darren J. Baker , James L. Kirkland , Tamar Tchkonia , Jan M. A. van Deursen , Yi Zhu
- 申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research
- 申请人地址： US CA Brisbane US CA Novato US MN Rochester
- 专利权人： UNITY BIOTECHNOLOGY, INC,BUCK INSTITUTE FOR RESEARCH ON AGING,MAYO FOUNDATION FOR MEDICAL EDUCATIOIN AND RESEARCH
- 当前专利权人： UNITY BIOTECHNOLOGY, INC,BUCK INSTITUTE FOR RESEARCH ON AGING,MAYO FOUNDATION FOR MEDICAL EDUCATIOIN AND RESEARCH
- 当前专利权人地址： US CA Brisbane US CA Novato US MN Rochester
- 代理机构： Wilson Sonsini Goodrich & Rosati
- 代理商 Michael Schiff
- 主分类号： A61K31/537
- IPC分类号： A61K31/537 ; A61K31/496 ; A61K31/495 ; A61K31/5377 ; A61K31/404 ; A61K31/4375 ; A61K31/428 ; A61K45/06 ; A61K9/00
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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