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公开(公告)号：US20240358311A1
公开(公告)日：2024-10-31
申请号：US18768686
申请日：2024-07-10
摘要： Systems, methods, devices, and other techniques for processing an ECG recording to assess a condition of a mammal. Assessing the condition of the mammal can include screening for atrial fibrillation, and screening for atrial fibrillation can include obtaining a first neural network input, the first neural network input representing an electrocardiogram (ECG) recording of the mammal, and processing the first neural network input with a neural network to generate an atrial fibrillation prediction for the mammal.
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公开(公告)号：US12130348B2
公开(公告)日：2024-10-29
申请号：US17793633
申请日：2021-01-15
发明人： Arvin Forghanian-Arani , Joshua D. Trzasko , Yi Sui , Philip A. Araoz , Richard L. Ehman , John Huston, III
IPC分类号： G01R33/563 , A61B5/00 , A61B5/055 , G01R33/48 , G06T11/00
CPC分类号： G01R33/56375 , A61B5/0051 , A61B5/055 , G01R33/4818 , G01R33/56358 , G06T11/003 , A61B5/0044 , G06T2210/41
摘要： Described here are systems and methods for a robust magnetic resonance elastography (“MRE”) imaging platform for rapid dynamic 3D MRE imaging. The imaging platform includes an MRE pulse sequence and advanced image reconstruction framework that work synergistically in order to greatly expand the domains where MRE can be deployed successfully.
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公开(公告)号：US20240353404A1
公开(公告)日：2024-10-24
申请号：US18634194
申请日：2024-04-12
IPC分类号： G01N33/564 , A61K38/13 , A61K39/00 , A61P13/12 , C07K16/28
CPC分类号： G01N33/564 , A61K38/13 , A61P13/12 , C07K16/2887 , A61K2039/505 , G01N2333/96411 , G01N2800/347
摘要： This document relates to methods and materials involved in identifying and/or treating mammals having membranous nephropathy (e.g., membranous nephropathy with an elevated level of a proprotein convertase subtilisin/kexin type 6 (PCSK6) polypeptide in kidney tissue such as the glomerular basement membrane (GBM)). For example, methods and materials for administering one or more immunosuppressive agents to treat a mammal (e.g., a human) identified as having membranous nephropathy are provided.
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4.发明公开公开(公告)号：US20240352120A1
公开(公告)日：2024-10-24
申请号：US18442934
申请日：2024-02-15
IPC分类号： C07K16/28 , A61K38/20 , A61K38/21 , A61K39/00 , C07K16/30 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/569 , G01N33/574
CPC分类号： C07K16/2803 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/215 , A61K38/217 , C07K16/2827 , C07K16/30 , C12N15/113 , C12N15/1138 , C12Q1/6886 , G01N33/5088 , G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N33/57438 , G01N33/57484 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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公开(公告)号：US20240343804A1
公开(公告)日：2024-10-17
申请号：US18294747
申请日：2022-08-17
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C12Q1/6886
CPC分类号： C07K16/2818 , A61P35/00 , C12Q1/6886 , A61K2039/505 , C12Q2600/158
摘要： This document provides methods and materials for assessing and/or treating mammals (e.g., humans) having mesothelioma (e.g., mesothelioma with a high junction burden). For example, methods and materials that can be used to determine whether or not a mammal having mesothelioma is likely to respond to a particular cancer treatment (e.g., immunotherapy with one or more immune checkpoint inhibitors) are provided. Methods and materials for treating a mammal (e.g., a human) having mesothelioma (e.g., mesothelioma with a high junction burden) where the treatment is selected based, at least in part, on whether or not the mammal is likely to respond to a particular cancer treatment (e.g., immunotherapy with one or more immune checkpoint inhibitors) also are provided.
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公开(公告)号：US20240338866A1
公开(公告)日：2024-10-10
申请号：US18747024
申请日：2024-06-18
发明人： Shengzhen Tao , Shuai Leng , Cynthia H. McCollough
CPC分类号： G06T11/008 , A61B6/032 , A61B6/5211 , A61B6/5258 , G06T5/50 , G06T5/70 , G06T11/005 , G06T2207/10081 , G06T2211/408 , G06T2211/424
摘要： A system and method is provided for high fidelity multi-energy CT processing. This system and method exploits prior knowledge, where prior knowledge may include redundant information existing in the CT images, such as spatial redundancy between a thick slice and a thin slice encompassed by or close to the thick slice, or the spatiospectral redundancy between the image output of multi-energy CT processing and the source multi-energy CT images. The system and method retains structural details, spatial resolution, spectral fidelity, and noise texture while achieving noise reduction. The method reduces image noise and increases the contrast-to-noise ratio in processed images, while simultaneously maintaining image details and natural appearance of the image to enhance detectability and facilitate reader acceptance.
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公开(公告)号：US12105088B2
公开(公告)日：2024-10-01
申请号：US17870477
申请日：2022-07-21
发明人： Vanda A. Lennon , Andrew McKeon , Boyan Fang , Shannon Hinson , Thomas J. Kryzer
IPC分类号： G01N33/53 , A61K49/06 , G01N33/564
CPC分类号： G01N33/564 , A61K49/06 , G01N2800/24
摘要： This document provides methods and materials involved in identifying and treating autoimmune GFAP (glial fibrillary acidic protein) astrocytopathy, a novel meningoencephalomyelitis, in humans as well as methods and materials for identifying and offering early treatment for patients having autoimmune GFAP astrocytopathy whose autoantibody profile predicts a high likelihood of having underlying cancer (e.g., adenocarcinoma or teratoma).
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8.发明公开公开(公告)号：US20240315663A1
公开(公告)日：2024-09-26
申请号：US18574543
申请日：2022-06-28
发明人： Mostafa Fatemi , Azra Alizad , David P. Rosen
IPC分类号： A61B8/08
CPC分类号： A61B8/085 , A61B8/0858
摘要： Systems and methods are provided for a mechanical analysis for determining a kinetic value, such as pressure, from ultrasonically measured Lamb wave speed in a pressurized biological compartment. Acoustoclastic analysis of Lamb waves may be used to determine pressure in a biological compartment, such as with a spherical pressure-vessel analysis. Non-invasive pressure estimation is provided in biological compartments which is relevant to a range of biological structures.
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公开(公告)号：US20240307681A1
公开(公告)日：2024-09-19
申请号：US18672957
申请日：2024-05-23
发明人： Justin Williams , Kip Ludwig , Erika Ross
CPC分类号： A61N1/056 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/0536 , A61N1/0551 , A61N1/36025 , A61N1/36034 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36132 , A61N1/36146 , A61N1/36175 , A61N1/37516
摘要： The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.
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公开(公告)号：US20240307414A1
公开(公告)日：2024-09-19
申请号：US18267024
申请日：2021-12-21
发明人： Liewei Wang , Huanyao Gao
IPC分类号： A61K31/58 , A61K31/136 , A61K31/454 , A61K31/506 , A61K31/519 , A61K31/704 , A61N5/10 , A61P35/00 , G01N33/574
CPC分类号： A61K31/58 , A61K31/136 , A61K31/454 , A61K31/506 , A61K31/519 , A61K31/704 , A61N5/10 , A61P35/00 , G01N33/57434
摘要： This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having prostate cancer. For example, methods and materials for determining whether or not a prostate cancer is likely to respond to a particular cancer treatment (e.g., an anti-androgen agent) are provided. Methods and materials for using one or more cancer treatments to treat a mammal (e.g., a human) identified as likely to respond to a particular cancer treatment are also provided.
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