Invention Grant
- Patent Title: Transthyretin allele selective UNA oligomers for gene silencing
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Application No.: US14667678Application Date: 2015-03-25
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Publication No.: US09982259B2Publication Date: 2018-05-29
- Inventor: Kiyoshi Tachikawa , Joseph E. Payne , Padmanabh Chivukula
- Applicant: Arcturus Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: Arcturus Therapeutics, Inc.
- Current Assignee: Arcturus Therapeutics, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Eckman Law Group
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K9/127 ; A61K31/713 ; A61K31/685
Abstract:
This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis. The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers. Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.
Public/Granted literature
- US20150307880A1 TRANSTHYRETIN ALLELE SELECTIVE UNA OLIGOMERS FOR GENE SILENCING Public/Granted day:2015-10-29
Information query
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