Technologies for bio-chemically controlling operation of a machine include applying a bio-chemical agent to an operator of the machine and controlling an operational characteristic of the machine based on the presence of the bio-chemical agent on the operator. The operational characteristic of the machine may be controlled based on the presence or lack of the biochemical agent on the operator. In some embodiments, the bio-chemical agent may be configured to generate a bio-chemical trigger in response to exposure to a biochemical or biological characteristic of the operator. The operation of the machine may be controlled based on such bio-chemical trigger or reaction.