- 专利标题： Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses
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申请号： US15480787申请日： 2017-04-06
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公开(公告)号： US09987266B2公开(公告)日： 2018-06-05
- 发明人: Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman , Chunjian Liu
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Elliott Korsen
- 优先权： ARP130104090 20131107
- 主分类号： A61K31/455
- IPC分类号： A61K31/455 ; A61K31/506
摘要：
Compounds having the following formula I: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
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