再颁专利
- 专利标题: Benzophenone glycinamide derivatives
- 专利标题(中): 二苯甲酮甘氨酰胺衍生物
-
申请号: US929383申请日: 1978-07-31
-
公开(公告)号: USRE30473E公开(公告)日: 1981-01-06
- 发明人: Cedric H. Hassall , William H. Johnson , Antonin Krohn , Carey E. Smithen , William A. Thomas
- 申请人: Cedric H. Hassall , William H. Johnson , Antonin Krohn , Carey E. Smithen , William A. Thomas
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: GBX36567/74 19740720; GBX21821/75 19750521; GBX36567/75 19750811
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07D213/50 ; C07D243/24 ; C07D249/08 ; C07K5/06 ; C07K5/065 ; C07K5/068 ; C07K5/072 ; C07K5/078
摘要:
This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula ##STR2## in which R.sup.a represents a hydrogen or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C-R.sup.b wherein R.sup.b represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R.sup.3 represents a phenyl, halophenyl or 2-pyridyl group and acid addition salts thereof.Also provided are methods for their preparation and intermediates thereof. These compounds exhibit activity as anticonvulsants, muscle relaxants and sedatives.
公开/授权文献
- US5499020A Data display radio pager 公开/授权日:1996-03-12