- 专利标题： Process for the preparation of epothilone analogs
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申请号： US11056606申请日： 2005-02-11
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公开(公告)号： USRE39356E1公开(公告)日： 2006-10-17
- 发明人: Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
- 申请人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Co.
- 当前专利权人： Bristol-Myers Squibb Co.
- 当前专利权人地址： US NJ Princeton
- 代理商 Anastasia P. Winslow
- 主分类号： C07D491/00
- IPC分类号： C07D491/00 ; C07D417/00
摘要：
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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